Donze H H, Lue C, Julian B A, Kutteh W H, Kantele A, Mestecky J
Department of Microbiology, University of Alabama at Birmingham, 35294, USA.
Clin Exp Immunol. 1997 Aug;109(2):356-61. doi: 10.1046/j.1365-2249.1997.4541352.x.
In mice, peritoneal B cells are composed of a unique B-1 cell population which can repopulate the intestinal lamina propria with IgA-producing cells, as well as contribute to the majority of serum IgM. In this study, peritoneal lymphocytes from patients starting continuous ambulatory peritoneal dialysis (CAPD) and from women undergoing bilateral tubal ligation (BTL) were analysed for the presence of a B-1 cell population as well as the expression of potential homing receptors. Up to 63% of the peritoneal B cells express surface antigen CD5, and most peritoneal lymphocytes express the mucosal homing receptors, alpha4 beta7 and alphaE beta7. When analysing serial samples collected from patients from the beginning of dialysis to 1 year, no marked changes were observed in serum or salivary immunoglobulin levels, although the peritoneal lymphocyte population was reduced by 50%. These data suggest that the phenotype of human peritoneal B-1 cells is similar to that of mice, but the contributions to the immune system may differ.
在小鼠中，腹膜B细胞由独特的B-1细胞群体组成，该群体能够用产生IgA的细胞重新填充肠固有层，并对大多数血清IgM的产生有贡献。在本研究中，分析了开始持续性非卧床腹膜透析（CAPD）的患者以及接受双侧输卵管结扎（BTL）的女性的腹膜淋巴细胞中B-1细胞群体的存在情况以及潜在归巢受体的表达。高达63%的腹膜B细胞表达表面抗原CD5，并且大多数腹膜淋巴细胞表达黏膜归巢受体α4β7和αEβ7。在分析从透析开始到1年期间从患者收集的系列样本时，尽管腹膜淋巴细胞群体减少了50%，但血清或唾液免疫球蛋白水平未观察到明显变化。这些数据表明，人类腹膜B-1细胞的表型与小鼠相似，但对免疫系统的贡献可能不同。
