复发性实验性自身免疫性葡萄膜视网膜炎（EAU）小鼠模型中的口服耐受：在致敏动物中诱导保护性耐受。
Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals.
作者信息
Thurau S R, Chan C C, Nussenblatt R B, Caspi R R
机构信息
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Clin Exp Immunol. 1997 Aug;109(2):370-6. doi: 10.1046/j.1365-2249.1997.4571356.x.
Oral administration of uveitogenic retinal antigens suppresses the expression of EAU induced by a subsequent immunization with these antigens. Effectiveness and mechanisms of oral tolerance in EAU have mainly been studied in the acute, monophasic model in Lewis rats by feeding antigen prior to induction of disease. In this study we investigated the effect of oral tolerance induction in the acute as well as the chronic-relapsing models in the B10.A mouse. In acute murine EAU we could effectively suppress disease by induction of oral tolerance prior to immunization. In the chronic-relapsing EAU, antigen feeding was started only after the animals had recovered from their first attack of uveitis. Under these experimental conditions the subsequent relapse was largely prevented. These experiments demonstrate that oral tolerance may have practical clinical implications in uveitis, which is predominantly a chronic-relapsing condition in humans.
口服致葡萄膜炎性视网膜抗原可抑制后续用这些抗原免疫诱导的实验性自身免疫性葡萄膜炎（EAU）的表达。EAU中口服耐受的有效性和机制主要是在Lewis大鼠的急性单相模型中，通过在疾病诱导前喂食抗原来进行研究的。在本研究中，我们调查了在B10.A小鼠的急性和慢性复发性模型中诱导口服耐受的效果。在急性小鼠EAU中，我们可以通过在免疫前诱导口服耐受来有效抑制疾病。在慢性复发性EAU中，仅在动物从首次葡萄膜炎发作中恢复后才开始喂食抗原。在这些实验条件下，很大程度上预防了随后的复发。这些实验表明，口服耐受在葡萄膜炎中可能具有实际的临床意义，而葡萄膜炎在人类中主要是一种慢性复发性疾病。
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