健康志愿者在控制性低压缺氧条件下促红细胞生成素的产生：进一步证明腺苷不起作用。
Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia: further evidence against a role for adenosine.
作者信息
Gleiter C H, Becker T, Wenzel J
机构信息
Abteilung Klinische Pharmakologie, Universität Göttingen, Germany.
出版信息
Br J Clin Pharmacol. 1997 Aug;44(2):203-5. doi: 10.1046/j.1365-2125.1997.00638.x.
AIMS
Objective of this study was to investigate whether adenosine modulates renal erythropoietin production.
METHODS
In the present study erythropoietin production was stimulated by hypobaric hypoxia by subjecting healthy volunteers to a simulated altitude of 4000 m in a low pressure chamber for 5.5 h. During exposure to hypoxia the subjects received i.v. in a randomized, single-blind, cross-over fashion the non-specific adenosine antagonist theophylline, the adenosine reuptake inhibitor dipyridamole and placebo.
RESULTS
Contrary to the working hypothesis, theophylline did not decrease and dipyridamole did not further boost erythropoietin concentrations.
CONCLUSIONS
The results are in agreement with our earlier study using haemorrhage as a controlled physiological stimulus of erythropoietin production, and would question a major role for adenosine as a mediator of renal erythropoietin production.
目的
本研究的目的是调查腺苷是否调节肾脏促红细胞生成素的产生。
方法
在本研究中，通过将健康志愿者置于低压舱中模拟海拔4000米5.5小时，利用低压缺氧刺激促红细胞生成素的产生。在缺氧暴露期间，受试者以随机、单盲、交叉方式静脉注射非特异性腺苷拮抗剂茶碱、腺苷再摄取抑制剂双嘧达莫和安慰剂。
结果
与工作假设相反，茶碱并未降低，双嘧达莫也未进一步提高促红细胞生成素浓度。
结论
这些结果与我们早期使用出血作为促红细胞生成素产生的受控生理刺激的研究一致，并对腺苷作为肾脏促红细胞生成素产生的介质的主要作用提出质疑。
Zotero 插件