Bdolah A, Kochva E, Ovadia M, Kinamon S, Wollberg Z
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
Toxicon. 1997 Aug;35(8):1251-61. doi: 10.1016/s0041-0101(97)00019-6.
The Egyptian mongoose (Herpestes ichneumon) is known for its resistance to viperid and elapid venoms. The current work demonstrates that it is also resistant to the venom of Atractaspis and its most toxic component, sarafotoxin-b. Intravenous administration of this toxin, at a dose of about 13 times LD100 for mice, resulted in disturbance in electrocardiograms in the mongoose, which returned to normal after several hours. Sarafotoxin-b failed to induce contraction of mongoose aortal preparations. Endothelin-1, which was demonstrated in tissue extracts of the mongoose by immunological methods, induced contraction of the isolated mongoose aorta. This contraction, however, was greatly reduced when endothelin-1 was applied on top of sarafotoxin-b. Binding studies revealed endothelin/sarafotoxin-specific binding sites in brain and cardiovascular preparations of the mongoose. It is suggested that some structural features of endothelin/sarafotoxin receptors in the mongoose enable them to differentiate between the two peptides.
埃及獴（Herpestes ichneumon）以其对蝰蛇科和眼镜蛇科毒液的抵抗力而闻名。目前的研究表明，它对穴蝰毒液及其最具毒性的成分——沙罗毒素 - b也具有抵抗力。以约为小鼠LD100的13倍剂量静脉注射这种毒素，导致埃及獴心电图出现紊乱，数小时后恢复正常。沙罗毒素 - b未能诱导埃及獴主动脉制剂收缩。通过免疫方法在埃及獴组织提取物中检测到的内皮素 - 1，可诱导离体埃及獴主动脉收缩。然而，当在内皮素 - 1之上施加沙罗毒素 - b时，这种收缩大大减弱。结合研究揭示了埃及獴脑和心血管制剂中存在内皮素/沙罗毒素特异性结合位点。有人认为，埃及獴体内内皮素/沙罗毒素受体的某些结构特征使它们能够区分这两种肽。
