Singh J, Ichhpujani R L, Prabha S, Chandra R, Khare S, Panda R C, Datta K K
National Institute of Communicable Diseases, Delhi, India.
Southeast Asian J Trop Med Public Health. 1996 Jun;27(2):274-8.
Blood samples from 171 full-term pregnant women (aged 18-38 years) of middle socioeconomic status from Delhi were tested for diphtheria antitoxins by indirect hemagglutination (IHA) test. History of primary immunization/clinical diphtheria during childhood was not ascertainable, but none had been revaccinated against diphtheria at any time. About 94% women had very high antitoxin titers (> or = 0.125 IU/ ml); none had antitoxin titer less than 0.015 IU/ml, the minimum protective level. The titers were uniformly high in all age groups. However, women having 2 or more children had significantly higher antitoxin titers than those having no or one child (p < 0.01). The results from this study and historical data on diphtheria in Delhi are compatible with continued transmission of C. diphtheriae in recent times in Delhi which is of sufficient magnitude to boost the antitoxin levels in adults, especially mothers having two or more children. The study highlights the need of increasing the immunization coverage with DPT among children to reduce the transmission of Corynebacterium diphtheriae.
对来自德里的171名社会经济地位中等的足月孕妇（年龄在18至38岁之间）的血样进行间接血凝试验（IHA）检测白喉抗毒素。无法确定其童年时期的初次免疫/临床白喉病史，但没有人曾在任何时候接种过白喉疫苗。约94%的女性抗毒素滴度非常高（≥0.125 IU/ml）；没有人的抗毒素滴度低于最低保护水平0.015 IU/ml。所有年龄组的滴度均一致很高。然而，有两个或更多孩子的女性的抗毒素滴度显著高于没有孩子或只有一个孩子的女性（p<0.01）。这项研究的结果以及德里白喉的历史数据表明，近期德里存在白喉杆菌的持续传播，其传播程度足以提高成年人，尤其是有两个或更多孩子的母亲的抗毒素水平。该研究强调了提高儿童白喉-百日咳-破伤风联合疫苗（DPT）免疫覆盖率以减少白喉杆菌传播的必要性。
