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巴雷特食管的监测:是否需要指南?

Surveillance of Barrett's esophagus: a need for guidelines?

作者信息

Ackroyd R, Wakefield S E, Williams J L, Stoddard C J, Reed M W

机构信息

Department of Surgery, Royal Hallamshire Hospital, Sheffield, UK.

出版信息

Dis Esophagus. 1997 Jul;10(3):185-9. doi: 10.1093/dote/10.3.185.

Abstract

Barrett's esophagus carries a 10-15% lifetime risk of malignant change, and dysplasia may be an early indication of such transformation. Endoscopic surveillance is widely practised but guidelines have not been established. A questionnaire regarding surveillance protocols was sent to all consultants in the Trent Region performing endoscopy (n = 79), of whom 58 (73%) replied. Surveillance is performed by 52 clinicians (90%), but the interval varies between 1 and 3 years. Routine biopsies are only taken by 38 (65%), of which 74% are taken randomly. Detection of low-grade dysplasia would lead 32 (62%) to reduce the surveillance interval. For high-grade dysplasia, a reduced surveillance interval or surgery is advocated by 36 (69%) and 13 (25%), respectively. Most clinicians (74%) discontinue surveillance at age 70 or 75. Surveillance of Barrett's esophagus is variable, especially in the presence of dysplasia. No surveillance guidelines are available, but most respondents (79%) believe these would help.

摘要

巴雷特食管患者一生中发生恶变的风险为10% - 15%,发育异常可能是这种转变的早期迹象。内镜监测广泛应用,但尚未制定相关指南。我们向特伦特地区所有从事内镜检查的顾问(共79人)发送了一份关于监测方案的调查问卷,其中58人(73%)进行了回复。52名临床医生(90%)开展监测工作,但监测间隔时间从1年到3年不等。只有38人(65%)进行常规活检,其中74%是随机活检。发现低度发育异常会使32人(62%)缩短监测间隔时间。对于高度发育异常,分别有36人(69%)和13人(25%)主张缩短监测间隔时间或进行手术。大多数临床医生(74%)在患者70岁或75岁时停止监测。巴雷特食管的监测情况各不相同,尤其是在存在发育异常的情况下。目前尚无监测指南,但大多数受访者(79%)认为指南会有所帮助。

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