Gibbins J M, Okuma M, Farndale R, Barnes M, Watson S P
Department of Pharmacology, University of Oxford, UK.
FEBS Lett. 1997 Aug 18;413(2):255-9. doi: 10.1016/s0014-5793(97)00926-5.
We have recently shown that collagen activates platelets through a pathway dependent on the Fc receptor gamma-chain and the tyrosine kinase Syk. We report here that the Fc receptor gamma-chain and the candidate collagen receptor glycoprotein VI (GPVI) co-associate. Furthermore, cross-linking GPVI stimulates a similar pattern of tyrosine phosphorylation to that stimulated by collagen, including tyrosine phosphorylation of Fc receptor gamma-chain. These results support a model where GPVI couples collagen-stimulation of platelets to phosphorylation of the Fc receptor gamma-chain leading to activation of Syk and phospholipase Cgamma2.
我们最近发现，胶原蛋白通过一条依赖于Fc受体γ链和酪氨酸激酶Syk的途径激活血小板。我们在此报告，Fc受体γ链与候选胶原蛋白受体糖蛋白VI（GPVI）共同缔合。此外，交联GPVI刺激的酪氨酸磷酸化模式与胶原蛋白刺激的相似，包括Fc受体γ链的酪氨酸磷酸化。这些结果支持了一种模型，即GPVI将血小板的胶原蛋白刺激与Fc受体γ链的磷酸化偶联起来，导致Syk和磷脂酶Cγ2的激活。
