[Pharmacological therapy of complicated Parkinson's disease].

The progression of Parkinson's disease, and the increase in the time under therapy with levodopa of this disease, leds to development of several complications, including loss of efficacy of the therapy, motor fluctuations, dyskinesias, psychiatric disorders, etc. These complications cause serious limitations to the management of the advanced disease. This article reviews the current status of the therapeutic approaches to the management of complicated Parkinson's disease.