Góngora-Biachi R A, González-Martínez P, Castro-Sansores C, Bastarrachea-Ortiz J
Laboratorio de Hematología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, México.
Ginecol Obstet Mex. 1997 Apr;65:141-4.
Southwestern Japan is an endemic zone with high prevalence of HTLV-I infection. In addition, a relation between cancer of the cervix and this retrovirus has been described. A recent study has demonstrated a low prevalence of HTLV-I/II infection in Yucatan, Mexico. However, cancer of the cervix is the most frequent oncological disease in this region. The objective of this study was to determine the relationship between cancer of the cervix and the HTLV-I/II infection. Sera from 123 patients with cancer of the cervix and 662 healthy women were screened for antibodies against HTLV-I/II by ELISA and agglutination test (PA). Results were confirmed by Western blot (WB). In the confirmed cases the differentiation between HTLV-I and HTLV-II was made by synthetic peptides. Only one woman (0.8%) had positive results in the patients group and two women (0.3%) had reactivity in the control group. In all these cases the antibodies were positive for HTLV-II. The prevalence in the group of patients with cancer of the cervix was similar to that of the control group. We therefore concluded that in Yucatan, Mexico there is no relation between HTLV-I/II infection and cancer of the cervix.
日本西南部是HTLV-I感染高流行的地方性区域。此外，已有关于子宫颈癌与这种逆转录病毒之间关系的描述。最近一项研究表明，在墨西哥尤卡坦半岛，HTLV-I/II感染的流行率较低。然而，子宫颈癌是该地区最常见的肿瘤疾病。本研究的目的是确定子宫颈癌与HTLV-I/II感染之间的关系。通过ELISA和凝集试验（PA）对123例子宫颈癌患者和662名健康女性的血清进行HTLV-I/II抗体筛查。结果通过蛋白质印迹法（WB）进行确认。在确诊病例中，通过合成肽区分HTLV-I和HTLV-II。患者组中只有一名女性（0.8%）结果呈阳性，对照组中有两名女性（0.3%）有反应性。在所有这些病例中，抗体对HTLV-II呈阳性。子宫颈癌患者组的流行率与对照组相似。因此，我们得出结论，在墨西哥尤卡坦半岛，HTLV-I/II感染与子宫颈癌之间没有关系。
