Distefano G, Betta P, Rodonò A, Tina L G, Sciotto A, Sciacca A, Romeo M G
Cattedra di Neonatologia, Istituto di Clinica Pediatrica II, Policlinico di Catania, Italia.
Pediatr Med Chir. 1997 Jan-Feb;19(1):27-30.
We prospectively determined serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) in the first 2 weeks of life in 32 preterm newborns in an attempt to assess whether these concentrations are reliable markers of sepsis in newborns at risk of infection. Ten of the study group were normal and had been hospitalized only for low birth weight. The remaining 22 presented respiratory distress (RDS) and were at even higher risk of infection because they required assisted mechanical ventilation and central venous catheterisation for parenteral feeding and infusion therapy. Sepsis was diagnosed in 11/22 newborns with RDS: in 3 on day 3 and in 8 on day 7. Circulating sICAM-1 concentrations were significantly elevated in neonates with RDS (group II) and associated infection (group III) compared with normal newborns (group I). However, after day 3 of life sICAM-1 values were significantly higher in group III than in group II.
我们前瞻性地测定了32例早产新生儿出生后前2周的血清可溶性细胞间黏附分子1（sICAM-1）浓度，以评估这些浓度是否是有感染风险的新生儿败血症的可靠标志物。研究组中有10例正常，仅因低出生体重住院。其余22例出现呼吸窘迫（RDS），由于需要辅助机械通气以及中心静脉置管进行肠外营养和输液治疗，感染风险更高。22例患有RDS的新生儿中有11例被诊断为败血症：3例在第3天，8例在第7天。与正常新生儿（I组）相比，患有RDS的新生儿（II组）和伴有感染的新生儿（III组）循环中的sICAM-1浓度显著升高。然而，出生后第3天之后，III组的sICAM-1值显著高于II组。
