Zhang L, Martelli M L, Battaglia C, Trapasso F, Tramontano D, Viglietto G, Porcellini A, Santoro M, Fusco A
Facoltà di Medicina e Chirurgia di Catanzaro, Università degli Studi di Reggio Calabria, via Tommaso Campanella 5, Catanzaro, 88100, Italy.
Exp Cell Res. 1997 Aug 25;235(1):62-70. doi: 10.1006/excr.1997.3659.
We have isolated a rat thyroid cDNA encoding a novel rat receptor-type tyrosine phosphatase protein. This gene, on the basis of its homology to another tyrosine phosphatase, the recently isolated human DEP-1/HPTPeta, has been named r-PTPeta. In rat thyroid cells the r-PTPeta gene acts as a differentiation marker. Indeed, the block of thyroid cell differentiation induced by viral and cellular oncogenes is associated with the inhibition or marked reduction of the expression of this gene, and its expression is positively regulated by thyrotropin, the physiological stimulator of thyroid cell growth.
我们分离出了一个编码新型大鼠受体型酪氨酸磷酸酶蛋白的大鼠甲状腺cDNA。基于该基因与另一种酪氨酸磷酸酶（最近分离出的人类DEP-1/HPTPeta）的同源性，它被命名为r-PTPeta。在大鼠甲状腺细胞中，r-PTPeta基因作为一种分化标志物。实际上，病毒癌基因和细胞癌基因诱导的甲状腺细胞分化受阻与该基因表达的抑制或显著降低有关，并且其表达受到促甲状腺激素（甲状腺细胞生长的生理性刺激因子）的正向调节。
