Robert J, Brown D M, Pasquier L D, Cohen N
University of Rochester Medical Center, Rochester, New York 14642, USA.
Exp Cell Res. 1997 Aug 25;235(1):227-37. doi: 10.1006/excr.1997.3672.
The thymocyte-specific cell surface molecule CTX is a developmentally regulated type I transmembrane protein of the immunoglobulin superfamily which, in the amphibian Xenopus, is exclusively expressed by a large fraction of cortical thymocytes and by different cell lines derived from independent spontaneous thymic tumors. Antibody cross-linking of CTX in vitro inhibits the growth of tumor cells and causes morphological alterations. Cells divide abnormally, accumulate in the G2/M phase of the cell cycle, and become multinucleated. This demonstrates, for the first time, that multinucleation can be induced by specifically cross-linking a cell surface molecule.
胸腺细胞特异性细胞表面分子CTX是免疫球蛋白超家族中一种受发育调控的I型跨膜蛋白，在两栖动物非洲爪蟾中，它仅由大部分皮质胸腺细胞以及源自独立自发胸腺肿瘤的不同细胞系表达。体外CTX的抗体交联可抑制肿瘤细胞的生长并引起形态学改变。细胞异常分裂，在细胞周期的G2/M期积累，并形成多核。这首次证明，通过特异性交联细胞表面分子可诱导多核化。
