Bobrzyński A
2nd Department of General Surgery, University School of Medicine, Cracow, Poland.
J Physiol Pharmacol. 1997 Jun;48 Suppl 3:1-56.
Changes in endocrine and secretory functions and in the morfology of gastric mucosa in the course of quadruple H. pylori eradication regimen in 50 H. pylori positive patients: 25 with duodenal ulcer (DU) and 25 with non ulcer dyspepsia (NUD) were studied and compared to 10 healthy controls. Therapy resulted in ulcer healing in all DU patients and in 92% eradication of H. pylori in both groups of patients-DU and NUD. In DU and NUD patients in the course of eradication significant decrease in plasma gastrin was observed. Somatostatin concentration in gastric juice increased significantly in DU patients after anti-H. pylori therapy. EGF in gastric content of DU and NUD patients has risen statistically significantly in the course of H. pylori eradication. Gastric acid output and volume flow decreased insignificantly in both groups. The elimination of H. pylori from gastric mucosa in both DU and NUD patients led to significant decrease in the density and activity of gastritis.
对50例幽门螺杆菌阳性患者（25例十二指肠溃疡患者和25例非溃疡性消化不良患者）进行四联幽门螺杆菌根除治疗，研究其内分泌和分泌功能以及胃黏膜形态学的变化，并与10名健康对照者进行比较。治疗使所有十二指肠溃疡患者溃疡愈合，十二指肠溃疡组和非溃疡性消化不良组患者的幽门螺杆菌根除率均为92%。在根除治疗过程中，十二指肠溃疡患者和非溃疡性消化不良患者的血浆胃泌素均显著降低。抗幽门螺杆菌治疗后，十二指肠溃疡患者胃液中生长抑素浓度显著升高。在幽门螺杆菌根除过程中，十二指肠溃疡患者和非溃疡性消化不良患者胃内容物中的表皮生长因子在统计学上显著升高。两组患者的胃酸分泌量和容积流量均略有下降。十二指肠溃疡患者和非溃疡性消化不良患者胃黏膜中幽门螺杆菌的清除导致胃炎的密度和活性显著降低。
