Magalhães A F, Almeida J R, Guerrazzi F, Yamanaka A, Mesquita M A, Trevisan M A, Ulson C M
Disciplina de Gastrenterologia, Dep. de Clínica Médica, FCM-Unicamp.
Rev Paul Med. 1991 Sep-Oct;109(5):197-203.
Prevalence of chronic gastritis and infection of the gastric mucosa by Helicobacter pylori in patients with non-ulcerating dyspepsia and duodenal ulcer. TYPE OF STUDY, SITE, PATIENTS: A prospective study was made of 48 consecutive patients with non-ulcerating dyspepsia of the dismotility type (NUD), and 13 consecutive patients with duodenal ulcer in activity (DU), selected from the gastroenterology outpatient clinic of the Clinical Hospital of the State University of Campinas (Unicamp).
Eight endoscopic biopsies (4 of the body and 4 of the gastric antrum) were performed on each of the patients to identify H. pylori, using three tests: urease, gram and histopathological examination.
Of the 48 patients with NUD, urease test was positive in 89.6% in the antrum and in 81.2% in the body; gram test was positive in 81.2% in the antrum and in 77.1% in the body; and H. pylori was identified in the histopathological examination in 79.2% in the antrum and in 70.8% in the gastric body. At least one of the three tests applied was positive in the mucosa of the gastric antrum in all 48 patients with NUD. In all 13 patients with DU, the three tests were positive in the gastric antrum, all of them with chronic gastritis of the antrum in the histopathological examination. Chronic gastritis of the gastric body with presence of H. pylori in the histopathological examination was found in 10 out of 13 patients. The urease test was positive in the mucosa of the gastric body in all DU cases.
The authors believed that the high prevalence of the tests used to identify H. pylori in patients with NUD can be explained by the selected group of patients, which belong to the low socio-economic class. The presence of H. pylori in the gastric mucosa of all patients with DU agrees with studies already published.
非溃疡性消化不良和十二指肠溃疡患者中慢性胃炎的患病率及胃黏膜幽门螺杆菌感染情况。研究类型、地点、患者：对从坎皮纳斯州立大学临床医院胃肠病门诊选出的48例连续性动力障碍型非溃疡性消化不良（NUD）患者和13例连续性活动期十二指肠溃疡（DU）患者进行了一项前瞻性研究。
对每位患者进行8次内镜活检（胃体4次，胃窦4次），采用尿素酶、革兰氏和组织病理学检查三项检测来鉴定幽门螺杆菌。
在48例NUD患者中，胃窦尿素酶试验阳性率为89.6%，胃体为81.2%；革兰氏试验胃窦阳性率为81.2%，胃体为77.1%；组织病理学检查胃窦幽门螺杆菌检出率为79.2%，胃体为70.8%。48例NUD患者中，胃窦黏膜三项检测中至少一项呈阳性。在所有13例DU患者中，三项检测在胃窦均为阳性，组织病理学检查均显示胃窦慢性胃炎。13例患者中有10例组织病理学检查发现胃体慢性胃炎伴幽门螺杆菌。所有DU病例胃体黏膜尿素酶试验均为阳性。
作者认为，用于鉴定NUD患者中幽门螺杆菌的检测高患病率可由所选患者群体属于低社会经济阶层来解释。所有DU患者胃黏膜中幽门螺杆菌的存在与已发表的研究结果一致。
