Lieb A S, Grooters A M, Tyler J W, Partington B P, Pechman R D
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803-8410, USA.
J Small Anim Pract. 1997 Aug;38(8):364-7. doi: 10.1111/j.1748-5827.1997.tb03487.x.
A four-year-old male affenpinscher was referred for evaluation of hindlimb weakness that had progressed to tetraparesis over a period of four weeks. Neurological examination was suggestive of a cervical spinal cord lesion. Radiographic examination revealed diffuse skeletal immaturity with open physes and epiphyseal dysplasia in long bones and vertebrae, consistent with a diagnosis of congenital hypothyroidism. Total and free serum T4 concentrations were very low, indicative of hypothyroidism. Survey radiographs of the cervical spine revealed a dorsally displaced Salter-Harris type I fracture of the cranial portion of the fourth cervical vertebra with the endplate present in the vertebral canal. Although signs of transverse myelopathy are uncommon in dogs with congenital hypothyroidism, they may be associated with either intervertebral disc protrusion or endplate displacement into the vertebral canal secondary to the epiphyseal abnormalities associated with congenital hypothyroidism.
一只四岁雄性阿芬平舍犬因后肢无力前来就诊，该症状在四周内逐渐发展为四肢轻瘫。神经学检查提示存在颈脊髓病变。影像学检查显示骨骼普遍发育不成熟，长骨和椎骨的骨骺开放且骨骺发育异常，符合先天性甲状腺功能减退的诊断。血清总T4和游离T4浓度极低，表明甲状腺功能减退。颈椎X线平片显示第四颈椎颅骨部分存在Salter-Harris I型背侧移位骨折，椎体终板位于椎管内。虽然先天性甲状腺功能减退的犬只很少出现横贯性脊髓病的体征，但它们可能与椎间盘突出或由于先天性甲状腺功能减退相关的骨骺异常继发的终板移位至椎管有关。
