Mizobe T
Department of Anesthesiology, Kyoto Prefectural University of Medicine.
Masui. 1997 Aug;46(8):1066-70.
Alpha 2 adrenergic agonists currently are used in the anesthetic management of the surgical patient for their sedative/hypnotic, anesthetic-sparing, analgesic, and sympatholytic properties. Experimental and clinical studies have progressed to the point where anesthesiologists are now focusing on the use of these agents for their analgesic and anesthetic effects. This interest has coincided with the development and clinical introduction of dexmedetomidine. Clinical studies using existing alpha 2 agonists have revealed a tremendous potential for these agents that will be fully realized when more selective and specific compounds become available.
α2肾上腺素能激动剂目前因其镇静/催眠、节省麻醉药、镇痛和抗交感神经特性，而被用于手术患者的麻醉管理。实验和临床研究已取得进展，麻醉医师目前正专注于使用这些药物来发挥其镇痛和麻醉作用。这种兴趣与右美托咪定的研发及临床应用相契合。使用现有α2激动剂的临床研究已揭示出这些药物的巨大潜力，当有更多选择性和特异性更强的化合物可用时，这种潜力将得到充分发挥。
