Adeyinka A, Pandis N, Bardi G, Bonaldi L, Mertens F, Mitelman F, Heim S
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1997 Sep;97(2):119-21. doi: 10.1016/s0165-4608(96)00390-1.
Chromosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had +12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These findings, especially when coupled with similar information on previously published cases, show that gain of chromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.
对短期培养的乳腺癌细胞进行染色体分析发现，4例存在12号染色体三体。在1例肿瘤中，这是唯一的异常情况。第2例显示细胞遗传学多克隆性，但主线的唯一变化是 +12。在其余2例肿瘤中，12号染色体三体是更复杂核型的一部分。这些发现，尤其是与先前发表病例的类似信息相结合时，表明12号染色体增加是乳腺癌发生过程中反复出现且有时较早出现的事件。
