van Niekerk F E, Cloete S W, Heine E W, van der Merwe G D, Wellington A, du Plessis S S, Bekker D
Department of Human and Animal Physiology, University of Stellenbosch, South Africa.
J S Afr Vet Assoc. 1996 Dec;67(4):209-13.
The effect of selenium (Se) supplementation of ewes with blood Se concentrations ranging between 100-200 ng/ml on embryonic survival during the early post-mating period (days 15-35) was studied in 4 trials. In the 1st 2 trials 137 ewes were used in 1991 and 118 in 1992. After being mated as a single flock, these ewes were stratified randomly into 3 groups. One group served as a control, the 2nd was injected with 1 ml Deposel (containing 50 mg Se as Ba selenate) and the 3rd group injected with 1 ml containing 1 mg Se as Na selenite. During 1991, supplementation was administered immediately after the mating period. It was postponed by 14 days in 1992. Parenteral Se supplementation reduced (p < 0.10) the number of ewes that lambed by > 19% during 1991 but not during 1992. The number of ewes producing twins was unaffected. In Trials 3 and 4 there was a consistent indication that parenteral Se supplementation of pregnant ewes between 15-35 days after mating resulted in a reduced (22-40%) embryonic survival rate, although significant (p < or = 0.10) differences were only observed after the pooling of treatments receiving parenteral Se supplementation. Drenching of ewes with 50 mg Se as Na selenite resulted in a similar tendency. Biochemical appraisal of the blood, kidney and liver Se status of ewes failed to reveal toxic levels. The possible mechanisms involved in impaired embryonic survival are unclear. Supplementation of ewes during the 1st month of pregnancy with parenteral Se preparations is not recommended.
在4项试验中，研究了对血液硒浓度在100 - 200 ng/ml之间的母羊补充硒（Se）对配种后早期（第15 - 35天）胚胎存活率的影响。在第1项和第2项试验中，1991年使用了137只母羊，1992年使用了118只。作为一个单群进行配种后，这些母羊被随机分为3组。一组作为对照，第二组注射1 ml Deposel（含50 mg硒，以亚硒酸钡形式存在），第三组注射1 ml含1 mg硒的亚硒酸钠。1991年，在配种期后立即进行补充。1992年推迟了14天。1991年，非肠道补充硒使产羔母羊数量减少（p < 0.10）超过19%，但在1992年没有。产双羔的母羊数量未受影响。在第3项和第4项试验中，有一致的迹象表明，在配种后15 - 35天对怀孕母羊进行非肠道补充硒会导致胚胎存活率降低（22 - 40%），尽管只有在汇总接受非肠道补充硒的处理后才观察到显著（p≤0.10）差异。用50 mg亚硒酸钠对母羊进行灌服也有类似趋势。对母羊血液、肾脏和肝脏硒状态的生化评估未发现有毒水平。胚胎存活率受损所涉及的可能机制尚不清楚。不建议在怀孕的第1个月对母羊进行非肠道硒制剂补充。
