Backer M M, Schreiber S, Pick C G
Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University, Israel.
Life Sci. 1997;61(9):PL109-13. doi: 10.1016/s0024-3205(97)00595-x.
To determine different serotoninergic antidepressants' effects on the gastrointestinal (GI) inhibiting effect induced by morphine, mice were pretreated with mianserin (a tetracyclic antidepressant with multiple 5-HT receptor subtypes interactions) and with fluoxetine (a selective 5-HT reuptake inhibitor). Mianserin alone, produced gastrointestinal inhibition in a dose-dependent manner. Naloxone did not reverse this inhibiting effect, indicating that different mechanism of action are involved in morphine- and mianserin-induced inhibition of the gastrointestinal transit. Fluoxetine injected alone produced an increased propulsive motility of the GI transit. This effect was not reversed by naloxone. Fluoxetine did not reduce significantly mianserin-induced inhibition of GI transit. Fluoxetine also mildly reversed morphine-induced gastrointestinal inhibition, suggesting some degree of involvement of the opiates through the serotoninergic system.
为了确定不同血清素能抗抑郁药对吗啡诱导的胃肠道（GI）抑制作用的影响，给小鼠预先使用米安色林（一种与多种5-羟色胺受体亚型相互作用的四环类抗抑郁药）和氟西汀（一种选择性5-羟色胺再摄取抑制剂）。单独使用米安色林以剂量依赖的方式产生胃肠道抑制作用。纳洛酮不能逆转这种抑制作用，表明吗啡和米安色林诱导的胃肠道转运抑制涉及不同的作用机制。单独注射氟西汀可使胃肠道转运的推进运动增加。这种作用不能被纳洛酮逆转。氟西汀不能显著降低米安色林诱导的胃肠道转运抑制。氟西汀也能轻度逆转吗啡诱导的胃肠道抑制，提示阿片类药物在一定程度上通过血清素能系统发挥作用。
