李斯特菌溶血素和IrpA是人类针对单核细胞增生李斯特菌的体液免疫反应的主要蛋白质靶点。
Listeriolysin and IrpA are major protein targets of the human humoral response against Listeria monocytogenes.
作者信息
Grenningloh R, Darji A, Wehland J, Chakraborty T, Weiss S
机构信息
National Research Center for Biotechnology, Department of Cell Biology and Immunology, Braunschweig, Germany.
出版信息
Infect Immun. 1997 Sep;65(9):3976-80. doi: 10.1128/iai.65.9.3976-3980.1997.
Abstract
We have examined the human humoral immune response directed against proteins of Listeria monocytogenes in both healthy individuals and listeriosis patients. Two major targets for an antibody response were found in individuals that did not suffer from listeriosis: listeriolysin (Hly) and the recently described internalin-related protein (IrpA). In contrast, the humoral response in listeriosis patients appears to be more heterogeneous and included Hly, IrpA, InlB, and ActA as major targets.
摘要
我们检测了健康个体和李斯特菌病患者针对单核细胞增生李斯特菌蛋白质的体液免疫反应。在未患李斯特菌病的个体中发现了抗体反应的两个主要靶点：李斯特菌溶血素（Hly）和最近描述的内化素相关蛋白（IrpA）。相比之下，李斯特菌病患者的体液反应似乎更加多样化，主要靶点包括Hly、IrpA、InlB和ActA。
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