Kumada M, Kuwaki T, Ju K H
St. Luke's College of Nursing.
Nihon Rinsho. 1997 Aug;55(8):1982-7.
Sympathetic nerve fibers innervating the heart and blood vessels exhibit tonic activity which originates from vasomotor neurons in the rostral ventrolateral medulla (RVLM). Whether sympathetic nerve activity (SNA) is elevated in humans with essential hypertension is still unsettled. Recording of muscle SNA (MSNA) by the microneurographic method mostly points to elevated SNA in hypertensives including borderline and mildly hypertensive patients. Exaggerated MSNA is most conspicuous in the accelerated hypertensives. Power spectral analyses of heart rate and blood pressure variability provide controversial results on this issue. Nevertheless, most studies demonstrate altered sympathetic cardiovascular control in hypertensive subjects. In young borderline hypertensives, the sympathetic response to mental stress or passive tilting is exaggerated, whereas in elderly subjects it is attenuated.
支配心脏和血管的交感神经纤维表现出紧张性活动，这种活动起源于延髓头端腹外侧区（RVLM）的血管运动神经元。原发性高血压患者的交感神经活动（SNA）是否升高仍未确定。通过微神经图法记录肌肉交感神经活动（MSNA）大多表明，包括临界高血压和轻度高血压患者在内的高血压患者的SNA升高。在急进型高血压患者中，MSNA过度增强最为明显。心率和血压变异性的功率谱分析在这个问题上提供了有争议的结果。然而，大多数研究表明高血压患者的交感神经对心血管的控制发生了改变。在年轻的临界高血压患者中，对精神压力或被动倾斜的交感神经反应增强，而在老年患者中则减弱。
