Shigetomi S
Futaba Kosei Hospital, Fukushima Prefectural Welfare Federation of Agricultural Co-operatives.
Nihon Rinsho. 1997 Aug;55(8):2055-60.
Alpha adrenergic receptors localized in blood vessels, heart, and kidneys as well as pre- and post-synaptic membrane are significantly important for controlling blood pressure. The treatment of alpha-adrenoceptor blocking drugs induce vasodilatation subsequently lowering blood pressure. Selective alpha-1 adrenoceptor blocking drugs (alpha-1 blockers) are recommended as a first line treatment of hypertension, because of their desirable effect on lipid and glucose metabolism. alpha-1 blockers decrease in total cholesterol and triglycerides, and increase in HDL-cholesterol. It is suggested that alpha-1 blockers improve insulin tolerance, cardiomegaly and atherosclerosis. Although they have many beneficial effect, we should consider adverse effects (orthostatic hypotension, flushing, etc.).
位于血管、心脏和肾脏以及突触前和突触后膜的α肾上腺素能受体对控制血压非常重要。α肾上腺素能受体阻断药物的治疗可诱导血管舒张，从而降低血压。由于选择性α-1肾上腺素能受体阻断药物（α-1阻滞剂）对脂质和葡萄糖代谢有良好作用，因此被推荐作为高血压的一线治疗药物。α-1阻滞剂可降低总胆固醇和甘油三酯，并提高高密度脂蛋白胆固醇水平。有人认为α-1阻滞剂可改善胰岛素耐受性、心脏肥大和动脉粥样硬化。尽管它们有许多有益作用，但我们也应考虑其不良反应（体位性低血压、脸红等）。
