Saito I, Saruta T
Health Center Keio University.
Nihon Rinsho. 1997 Aug;55(8):2086-90.
Over the past few decades, numerous randomized controlled studies of the treatment of hypertension have been conducted in Western countries to determine whether blood pressure reduction reduces the risk of stroke and myocardial infarction. Diuretics and beta blockers, because they have been shown in clinical trials to reduce cardiovascular morbidity and mortality, are the preferred drugs of first choice. No direct evidence yet supports the theoretical advantages of calcium channel blockers and ACE inhibitors over diuretics and beta blockers. Because East Asian nations differ culturally from Western countries, it is very difficult to conduct a randomized trials, thus, there were no reports of large, long-term, randomized placebo-controlled clinical trials of hypertension.
在过去几十年里，西方国家进行了大量关于高血压治疗的随机对照研究，以确定血压降低是否能降低中风和心肌梗死的风险。利尿剂和β受体阻滞剂，由于在临床试验中已显示能降低心血管疾病的发病率和死亡率，是首选药物。尚无直接证据支持钙通道阻滞剂和血管紧张素转换酶抑制剂相对于利尿剂和β受体阻滞剂的理论优势。由于东亚国家在文化上与西方国家不同，很难进行随机试验，因此，没有关于高血压的大型、长期、随机安慰剂对照临床试验的报告。
