Myers G, Lu H, Calef C, Leitner T
Los Alamos National Laboratory, NM 87545, USA.
Semin Cancer Biol. 1996 Dec;7(6):349-58. doi: 10.1006/scbi.1996.0044.
The classification of the papillomaviral sequence into types is satisfactory for many purposes, but the resulting catalog does not accurately depict the extent of diversification of this family of viruses. Phylogenetic and mutational analyses reveal that some viral forms are much more ancient than other forms. Episodic evolutionary events and zoonotic transmission may have contributed to the overall pattern. Convergent evolution appears to be the best explanation for the scattered occurrence across the family tree of viruses with high oncogenic risk. We look for the determinants of this risk among the less conserved residues of the viral E6 and E7 transforming proteins.
乳头瘤病毒序列的分型在许多方面都令人满意，但由此产生的分类目录并不能准确描述该病毒家族的多样化程度。系统发育和突变分析表明，一些病毒形式比其他形式更为古老。偶发的进化事件和人畜共患传播可能促成了总体格局。趋同进化似乎是对具有高致癌风险的病毒在整个病毒家族树中分散出现的最佳解释。我们在病毒E6和E7转化蛋白保守性较低的残基中寻找这种风险的决定因素。
