Fideleff H L, Boquete H, Ruibal G, Suärez M, Sobrado P, Zanchetti F, Perco M, Holland M
Unidad de Endocrinologia, Hospital Municipal T. Alvarez, Buenos Aires, Argentina.
Medicina (B Aires). 1996;56(6):679-82.
Hormonal, clinical and scrotal Doppler findings were assessed in 16 prepubertal patients having unilateral varicocele. As already described in pubertal patients, Doppler studies made it possible to detect patterns of prolonged, intermittent or permanent reflux. An LH-RH test and an hCG test measuring LH, FSH and testosterone (T) were performed in all cases. Patients with varicocele showed (median and range): LH B (mlU/ml): 0.40 (0.40-2.1); LH Mx.: 3.7 (1.1-15); FSH B (mlU/ml): 1.95 (0.40-4.5); FSH Mx.: 4.9 (3.1-10); T B (ng/ml): 0.2 (0.1-1.5); T Post.: 2.25 (0.82-11.5). The control group showed: LH B (mlU/ml): 0.40 (0.4-0.85); LH Mx.: 2.15 (0.63-12) FSH B (mlU/ml): 1.45 (0.4-3); FSH Mx.: 4.25 (2.6-5.9); T B (ng/ml): 0.1 (0.1-0.3); T Post.: 3.26 (1.0-5.6). No significant differences were found between the hormonal results of the different groups classified according to the scrotal findings. Basal LH and FSH in grade 3 varicoceles were found to be significantly higher (p < 0.05) than those of the control group. Basal T, as well as the maximal response of both gonadotropins to LH-RH, and T response to hCG showed no significant differences with reference to the control group. Our findings provide indirect support to the notion that the gonadal damage would become detectable from puberty onwards.
对16例青春期前单侧精索静脉曲张患者的激素、临床及阴囊多普勒检查结果进行了评估。正如在青春期患者中已经描述的那样，多普勒研究能够检测到持续、间歇性或永久性反流的模式。所有病例均进行了LH-RH试验以及测量LH、FSH和睾酮（T）的hCG试验。精索静脉曲张患者的结果显示（中位数及范围）：基础LH（mIU/ml）：0.40（0.40 - 2.1）；LH最大值：3.7（1.1 - 15）；基础FSH（mIU/ml）：1.95（0.40 - 4.5）；FSH最大值：4.9（3.1 - 10）；基础T（ng/ml）：0.2（0.1 - 1.5）；注射hCG后T：2.25（0.82 - 11.5）。对照组结果显示：基础LH（mIU/ml）：0.40（0.4 - 0.85）；LH最大值：2.15（0.63 - 12）；基础FSH（mIU/ml）：1.45（0.4 - 3）；FSH最大值：4.25（2.6 - 5.9）；基础T（ng/ml）：0.1（0.1 - 0.3）；注射hCG后T：3.26（1.0 - 5.6）。根据阴囊检查结果分类的不同组之间，激素结果未发现显著差异。3级精索静脉曲张患者的基础LH和FSH显著高于对照组（p < 0.05）。基础T以及两种促性腺激素对LH-RH的最大反应，以及T对hCG的反应与对照组相比无显著差异。我们的研究结果为性腺损伤从青春期开始就可检测到这一观点提供了间接支持。
