Fundia A, Larripa I
Departamento de Genética, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Medicina (B Aires). 1996;56(6):727-32.
Structural and numerical chromosomal abnormalities are frequent findings in neoplastic cells. The origin of structural rearrangements is probably due to the existence of specific labile areas on human chromosomes. These areas, named fragile sites (FS), are prone to chromosomal breakage and rearrangements, playing an important role in the first steps of carcinogenesis. The classification of FS, the mechanisms involved in FS induction and their biological significance, specially their relationship with cancer development, are discussed.
结构和数量染色体异常是肿瘤细胞中的常见现象。结构重排的起源可能归因于人类染色体上特定不稳定区域的存在。这些区域被称为脆性位点（FS），易于发生染色体断裂和重排，在致癌作用的起始阶段发挥重要作用。本文讨论了脆性位点的分类、诱导脆性位点的机制及其生物学意义，特别是它们与癌症发展的关系。
