Giacomello A, Di Sciascio N, Quaratino C P
Department of Oncology and Neurosciences, University of Chieti, Italy.
Metabolism. 1997 Sep;46(9):1085-9. doi: 10.1016/s0026-0495(97)90283-3.
The relations between serum urate levels and age, serum cholesterol, creatinine, glucose, and triglyceride concentrations were studied in 930 men and 298 premenopausal and 478 postmenopausal women, taking into account the renal handling of uric acid. All subjects were outpatients, and statistical evaluation was performed on cases corresponding to the central 95th percentile of the biochemical variables measured. An alternative analysis excluding subjects with serum glucose or creatinine levels outside the normal range was also performed. In men, premenopausal and postmenopausal women, and their normoglycemic normocreatininemic subsets, serum triglyceride level was positively correlated with serum urate concentration and inversely correlated with fractional urate excretion in both simple and multiple linear regression analysis. In men and postmenopausal women, there was also a strong positive independent association between serum urate and creatinine levels. This association was significant also in the normoglycemic normocreatininemic subset of men, but it was insignificant in normoglycemic normocreatininemic postmenopausal women. In this large cross-sectional study, a negative correlation between serum triglyceride concentration and renal uric acid excretion has been demonstrated.
在930名男性、298名绝经前女性和478名绝经后女性中，研究了血清尿酸水平与年龄、血清胆固醇、肌酐、葡萄糖和甘油三酯浓度之间的关系，并考虑了肾脏对尿酸的处理。所有受试者均为门诊患者，对测量的生化变量处于中心第95百分位数的病例进行了统计评估。还进行了一项排除血糖或肌酐水平超出正常范围受试者的替代分析。在男性、绝经前和绝经后女性及其血糖正常、肌酐正常的亚组中，在简单和多元线性回归分析中，血清甘油三酯水平与血清尿酸浓度呈正相关，与尿酸排泄分数呈负相关。在男性和绝经后女性中，血清尿酸和肌酐水平之间也存在强烈的正独立关联。这种关联在男性血糖正常、肌酐正常的亚组中也很显著，但在血糖正常、肌酐正常的绝经后女性中不显著。在这项大型横断面研究中，已证明血清甘油三酯浓度与肾脏尿酸排泄之间存在负相关。
