Dodd L G, Scully S, Layfield L J
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Diagn Cytopathol. 1997 Sep;17(3):200-4. doi: 10.1002/(sici)1097-0339(199709)17:3<200::aid-dc6>3.0.co;2-i.
The epithelioid variant of malignant peripheral nerve sheath tumor (MPNST), also known as malignant epithelioid schwannoma, is a relatively rare and recently characterized clinicopathologic entity. The epithelioid variant of MPNST shares many clinical features with conventional MPNST but is characterized by different histologic and cytologic features. These include a distinctive nesting pattern and an abundance of cytoplasm not seen in histology of conventional nerve sheath tumors. Cytologically, the epitheliod variant shows a propensity to cellular discohesiveness and a plasmacytoid or epitheliod appearance that is in contradistinction to the spindled appearance of the usual MPNST. Herein, we report our experience with fine-needle aspiration (FNA) of two epithelioid malignant schwannomas and discuss the FNA cytologic differential diagnosis.
恶性外周神经鞘瘤（MPNST）的上皮样变体，也称为恶性上皮样神经鞘瘤，是一种相对罕见且最近才得以明确特征的临床病理实体。MPNST的上皮样变体与传统MPNST具有许多临床特征，但具有不同的组织学和细胞学特征。这些特征包括独特的巢状模式以及传统神经鞘瘤组织学中未见的丰富细胞质。在细胞学上，上皮样变体表现出细胞解离倾向以及浆细胞样或上皮样外观，这与通常MPNST的梭形外观形成对比。在此，我们报告了两例上皮样恶性神经鞘瘤细针穿刺抽吸（FNA）的经验，并讨论了FNA的细胞学鉴别诊断。
