Matsuoka M, Nomaguchi H, Yukitake H, Ohara N, Matsumoto S, Mise K, Yamada T
National Institute for Leprosy Research, Tokyo, Japan.
Vaccine. 1997 Aug;15(11):1214-7. doi: 10.1016/s0264-410x(97)00018-2.
Immunization of mice with the ribosomal fraction from ruptured Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and the culture filtrate reduced remarkably the multiplication of Mycobacterium leprae in the foot pads of mice. This is the first reported case of the protective activity against M. leprae multiplication in mice of the BCG ribosomal fraction and culture filtrate. The inhibition was more evident with the culture filtrate than with the ribosomal fraction. When the ribosomal proteins separated from ribosomal RNA were injected into mice, only slight inhibition was observed. Ribosomal RNA alone did not inhibit at all, in contrast to the conclusion reported by Youmans and Youmans.
用来自破裂的牛分枝杆菌卡介苗（BCG）的核糖体组分和培养滤液对小鼠进行免疫，可显著减少麻风分枝杆菌在小鼠脚垫中的繁殖。这是首次报道BCG核糖体组分和培养滤液对小鼠体内麻风分枝杆菌繁殖具有保护活性的案例。培养滤液的抑制作用比核糖体组分更明显。当将从核糖体RNA中分离出的核糖体蛋白注射到小鼠体内时，仅观察到轻微的抑制作用。与尤曼斯和尤曼斯报道的结论相反，单独的核糖体RNA根本没有抑制作用。
