Bender A, Sapp M, Feldman M, Reddy A, Seder R, Schuler G, Steinman R M, Bhardwaj N
Rockefeller University, New York 10021, USA.
Adv Exp Med Biol. 1997;417:383-7. doi: 10.1007/978-1-4757-9966-8_62.
The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example, together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.
体外产生针对甲型流感病毒的高效人CD8 + 细胞毒性T淋巴细胞（CTL）的细胞要求已明确。此外，我们已开发出从非增殖祖细胞产生大量树突状细胞（DC）的改进方法。这些进展使得设计在体内引发CTL的新策略成为可能。例如，与白细胞介素-12一起，抗原脉冲DC可能是增强针对感染因子和恶性肿瘤的CTL反应的有用方法。我们的结果还重新开启了将灭活病毒制剂用作CTL反应免疫原的潜在用途。
