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Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines.

作者信息

von Zezschwitz C, Vorwerk H, Tergau F, Steinfelder H J

机构信息

Institute of Pharmacology and Toxicology, University of Göttingen, Germany.

出版信息

FEBS Lett. 1997 Aug 11;413(1):147-51. doi: 10.1016/s0014-5793(97)00896-x.

DOI:10.1016/s0014-5793(97)00896-x
PMID:9287133
Abstract

Two epithelial tumour lines, HeLa and KB, were treated with okadaic acid and calyculin A, specific inhibitors of Ser/Thr phosphatases (PP), esp. PP1 and PP2A. Morphological criteria, analysis of DNA fragmentation and studies of membrane integrity revealed that both agents concentration- and time-dependently induced apoptosis at nanomolar concentrations which in these cells was associated with the stimulation of a transglutaminase activity. Since a non-functional derivative of okadaic acid did not affect cell viability apoptosis was apparently related to the inhibition of PP1 and PP2A. Membrane damage marker activity was delayed by at least 24 h when compared to nuclear alterations.

摘要

相似文献

1
Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines.
FEBS Lett. 1997 Aug 11;413(1):147-51. doi: 10.1016/s0014-5793(97)00896-x.
2
Inhibitors of ser/thr phosphatases 1 and 2A induce apoptosis in pituitary GH3 cells.丝氨酸/苏氨酸磷酸酶1和2A的抑制剂可诱导垂体GH3细胞凋亡。
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The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells.
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Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways.蛋白磷酸酶1和2A的抑制剂以不同方式阻止内源性和外源性凋亡途径。
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PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress.PP1/PP2A磷酸酶抑制剂冈田酸和花萼海绵诱癌素A可阻断生长因子和氧化应激对ERK5的激活作用。
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6
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.脂肪细胞中磷酸二酯酶3B（PDE3B）对丝氨酸/苏氨酸磷酸酶抑制剂的反应：磷酸化与激活；2A型蛋白磷酸酶在体外使PDE3B失活
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T cell apoptosis induced by interleukin-2 deprivation or transforming growth factor-beta 2: modulation by the phosphatase inhibitors okadaic acid and calyculin A.白细胞介素-2缺乏或转化生长因子-β2诱导的T细胞凋亡：磷酸酶抑制剂冈田酸和花萼海绵诱癌素A的调节作用
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8
Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax.冈田酸诱导的晶状体上皮细胞凋亡需要抑制磷酸酶-1，且与包括p53和bax在内的基因表达诱导有关。
Eur J Biochem. 1998 Oct 15;257(2):351-61. doi: 10.1046/j.1432-1327.1998.2570351.x.
9
Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis.花萼海绵诱癌素A是一种有效的磷酸酶-1和磷酸酶-2A抑制剂，可防止细胞凋亡。
Biochem Biophys Res Commun. 1993 Jan 15;190(1):47-55. doi: 10.1006/bbrc.1993.1009.
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Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells.蛋白激酶C对钠-钾-氯协同转运体的下调作用是由色素性睫状上皮细胞中的蛋白磷酸酶1介导的。
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