树突状细胞和滤泡树突状细胞在HIV感染及发病机制中的作用

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis.

作者信息

Grouard G, Clark E A

机构信息

Regional Primate Research Center, Department of Microbiology, University of Washington Medical Center, Seattle, WA 98195, USA.

出版信息

Curr Opin Immunol. 1997 Aug;9(4):563-7. doi: 10.1016/s0952-7915(97)80111-2.

DOI:10.1016/s0952-7915(97)80111-2

PMID:9287189

Abstract

Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

摘要

树突状细胞（DCs）和滤泡树突状细胞（FDCs）在HIV介导的发病机制中发挥着重要作用。最近的研究确定了新的DC亚群，并表明淋巴黏膜中的DCs既能携带病毒，又能刺激病毒传播到CD4(+) T细胞中。FDCs携带未剪接的HIV mRNA和免疫复合物形式的病毒，但不携带具有活性感染力的病毒，然而这些细胞是病毒粒子的关键调控储存库。