Teshima A, Harada M
Department of Medicine II, Okayama University Medical School, Japan.
Cytokines Cell Mol Ther. 1997 Jun;3(2):101-14.
Allogeneic transplantation of peripheral blood stem/progenitor cells (PBSC/PBPC) has been increasingly used as an alternative to allogeneic bone marrow transplantation. To mobilize and collect a sufficient number of PBSC/PBPC for engraftment after allotransplantation, granulocyte colony-stimulating factor (G-CSF) has been preferentially used. The mobilization protocol, however, has not been fully established. In this review, dose and schedule of G-CSF administration, characteristics of G-CSF-mobilized PBPC products, cytokines other than G-CSF for PBSC/PBPC mobilization, and safety of the PBSC/PBPC donors are discussed for clinical application of allogeneic PBSC/PBPC transplantation.
外周血干细胞/祖细胞（PBSC/PBPC）的异基因移植已越来越多地被用作异基因骨髓移植的替代方法。为了在同种异体移植后动员和收集足够数量的PBSC/PBPC用于植入，已优先使用粒细胞集落刺激因子（G-CSF）。然而，动员方案尚未完全确立。在本综述中，讨论了G-CSF给药的剂量和方案、G-CSF动员的PBPC产品的特性、用于PBSC/PBPC动员的G-CSF以外的细胞因子以及PBSC/PBPC供体的安全性，以用于异基因PBSC/PBPC移植的临床应用。
