Takahashi Y, Kubo T
Department of Otolaryngology, Osaka University Medical School, Japan.
Acta Otolaryngol Suppl. 1997;528:56-8.
In vitro brainstem slice preparations have provided the opportunity to obtain accurate information about the neuropharmacology of the vestibular system. By stimulating the root of the eighth cranial nerve, excitatory synaptic transmission in the rat medial vestibular nucleus has been observed and analyzed with extra- and intra-cellular recordings. Recently, tight-seal, whole-cell recordings, perforated whole-cell recordings and microfluorometry of Ca2+ were applied to in vitro brainstem slice preparations to obtain detailed information. Excitatory synaptic transmission to MVN neurons is reviewed.
体外脑干切片标本为获取有关前庭系统神经药理学的准确信息提供了契机。通过刺激第八对脑神经的根部,已利用细胞外和细胞内记录观察并分析了大鼠内侧前庭核中的兴奋性突触传递。最近,紧密封接全细胞记录、穿孔全细胞记录以及Ca2+的微量荧光测定法被应用于体外脑干切片标本,以获取详细信息。本文对向内侧前庭核神经元的兴奋性突触传递进行了综述。