异山梨醇对实验性诱导的积水耳中畸变产物耳声发射和内淋巴直流电电位的影响。

Effect of isosorbide on distortion-product otoacoustic emissions and endocochlear DC potential in experimentally induced hydropic ears.

作者信息

Okubo H, Tachihara N, Satoh S, Hara A, Kusakari J

机构信息

Department of Otolaryngology, University of Tsukuba, Japan.

出版信息

Acta Otolaryngol Suppl. 1997;528:59-62.

PMID:9288240

Abstract

The effects of isosorbide on distortion-product otoacoustic emissions (DPOAEs) and endocochlear DC potential (EP) were examined in experimentally induced endolymphatic hydropic ears and untreated control ears using 20 albino guinea pigs. DPOAEs and EP in the hydropic ears decreased after obliteration of the endolymphatic duct and sac. The administration of isosorbide restored DPOAEs to the normal level, whereas EP was further reduced. In control ears there was no significant change in DPOAEs and EP after the administration of isosorbide. The results obtained in the present study indicate that the effect of isosorbide on DPOAEs is different from that on EP, and the recovery of DPOAEs in hydropic ears is not a secondary phenomenon due to the recovery of EP.

摘要

使用20只白化豚鼠，研究了异山梨醇对实验性诱导的内淋巴积水耳和未处理的对照耳中的畸变产物耳声发射（DPOAE）和内耳蜗直流电位（EP）的影响。内淋巴管和内淋巴囊闭塞后，积水耳中的DPOAE和EP降低。异山梨醇给药后，DPOAE恢复到正常水平，而EP进一步降低。在对照耳中，异山梨醇给药后DPOAE和EP没有显著变化。本研究获得的结果表明，异山梨醇对DPOAE的作用与对EP的作用不同，积水耳中DPOAE的恢复不是由于EP的恢复而产生的继发现象。