The effects of ninjinyoeito on cultured venous endothelial cells.

The effects of Ninjinyoeito on endothelial cells in human umbilical veins was examined. We found that Ninjinyoeito accelerates the inhibition and decomposition of Endothelin-1 production, which is known to constrict veins and raise blood pressure, and promote the synthesis of nitric oxicide which is known to have a vasophypotonic effect. We also found that Ninjinyoeito accelerates Interleukin 1-beta (IL-1 beta) production. IL-1 beta is a substance that plays important roles in maintaining the homeostasis of living organisms in immunity and inflammation, for example, as well as in the production of tissue plasminogen activators, which are known to have an anti-thrombotic effect on blood coagulation and on the fibrinolysis mechanism. Thus, it is suggested that Ninjinyoeito is effective in accelerating the physiological functions of human vein endothelial cells in vitro.