Bitar M S
Kuwait University, School of Medicine, Department of Pharmacology and Toxicology, Safat, Kuwait.
Horm Metab Res. 1997 Aug;29(8):383-6. doi: 10.1055/s-2007-979060.
Impaired wound healing is an enigmatic and debilitating complication of diabetes. A consensus as to the pathogenesis of this disorder has yet to emerge. Recent concepts suggest that IGF-1 is an important regulator of the healing process. The level of this growth factor is reduced in the wound environment of diabetics. We tested the premise that IGF-1 administration may prevent or ameliorate wound healing impairment in streptozotocin (STZ, 55 mg/kg, iv) diabetic rats. IGF-1 (15 micrograms/day) or placebo was infused via mini-osmotic pumps into standardized stainless steel dorsal wound chambers. Wound-related parameters including protein, DNA, hydroxyproline and macrophages were decreased as a function of diabetes. A 14-day treatment with IGF-1 reversed the diabetes effect and increased total hydroxyproline, DNA, protein and macrophage numbers by 48%, 52%, 31% and 40% above vehicle-control values, respectively. The data support the premise that diabetes, related suppression of IGF-1 and/or macrophage function within the wound environment is responsible, at least in part, for the wound healing impairment in this disease state.
伤口愈合受损是糖尿病一种难以捉摸且使人衰弱的并发症。关于这种病症的发病机制尚未达成共识。最近的观点认为胰岛素样生长因子-1（IGF-1）是愈合过程的重要调节因子。在糖尿病患者的伤口环境中，这种生长因子的水平会降低。我们验证了一个假设，即给予IGF-1可能预防或改善链脲佐菌素（STZ，55毫克/千克，静脉注射）诱导的糖尿病大鼠的伤口愈合受损情况。通过微型渗透泵将IGF-1（15微克/天）或安慰剂注入标准化的不锈钢背部伤口腔室。与伤口相关的参数，包括蛋白质、DNA、羟脯氨酸和巨噬细胞数量，均随着糖尿病病情发展而减少。用IGF-1进行14天的治疗逆转了糖尿病的影响，使总羟脯氨酸、DNA、蛋白质和巨噬细胞数量分别比载体对照值增加了48%、52%、31%和40%。这些数据支持了这样一种假设，即糖尿病相关的伤口环境中IGF-1抑制和/或巨噬细胞功能至少在一定程度上导致了这种疾病状态下的伤口愈合受损。
