Grzelewska-Rzymowska I, Kroczyńska-Bednarek J, Grabski W, Cieślewicz G, Bara A, Rozniecki J
Kliniki Pneumonologii i Alergologii AM w Lodzi.
Pneumonol Alergol Pol. 1997;65(1-2):45-52.
The study was performed in 11 patients suffering from stable mild and moderate atopic asthma. Bronchial allergen challenges were performed according to Chai et al method. Airway hyperreactivity-AH (PC20H in mg/ml) was determined in each study day before subthreshold allergen inhalation dose, meaning the dose which did not induce asthmatic responses. Then FEV1 was measured in 2, 5, 15, 30 i 60 min. after allergen provocation throughout 4 to 9 consecutive days. A significant increase of PC20H was observed in 8 patients (xg PC20H in whole group decreased from 0.93 to 0.35 mg/ml after allergen challenges). The authors conclude that allergen inhalation challenge without asthmatic bronchial responses can cause an increase AH.
该研究针对11例患有稳定型轻度和中度特应性哮喘的患者开展。支气管过敏原激发试验按照柴氏等人的方法进行。在低于阈值的过敏原吸入剂量（即未诱发哮喘反应的剂量）前，于每个研究日测定气道高反应性（AH，以mg/ml为单位的PC20H）。然后在连续4至9天内，于过敏原激发后2、5、15、30和60分钟测量第一秒用力呼气容积（FEV1）。8例患者观察到PC20H显著增加（过敏原激发后全组的几何平均PC20H从0.93降至0.35mg/ml）。作者得出结论，无哮喘性支气管反应的过敏原吸入激发可导致气道高反应性增加。
