Hagedorn B, Kostenbauder H B
Res Commun Chem Pathol Pharmacol. 1977 Nov;18(3):495-506.
Cigarette smoke administration was previously found to have a pronounced inhibitory effect on metabolism of nicotine and benzo[a]pyrene in the isolated perfused rabbit lung. These observations suggest the possibility of tobacco smoke inhibition of biotransformations associated with non-ventilatory pulmonary functions such as metabolic clearance of endogenous vasoactive substances. However, studies of the effect of smoke on uptake and metabolism of PGF2alpha in isolated perfused rabbit lungs provide no evidence of inhibition of these processes.
先前发现，给予香烟烟雾对离体灌注兔肺中尼古丁和苯并[a]芘的代谢具有显著的抑制作用。这些观察结果表明，烟草烟雾有可能抑制与非通气性肺功能相关的生物转化，如内源性血管活性物质的代谢清除。然而，关于烟雾对离体灌注兔肺中PGF2α摄取和代谢影响的研究并未提供这些过程受到抑制的证据。
