β-肾上腺素能受体激动剂KWD 2131对人肺组织的抗过敏及支气管扩张作用

Anti-anaphylactic and bronchodilating action of a beta-adrenoceptor stimulator, KWD 2131, in human lung tissue.

作者信息

Strandberg K, Pegelow K O, Persson C G, Sörenby L

出版信息

Allergy. 1979 Aug;34(4):221-4. doi: 10.1111/j.1398-9995.1979.tb01702.x.

DOI:10.1111/j.1398-9995.1979.tb01702.x

Abstract

The beta-adrenoceptor stimulating agent KWD 2131 has been studied with regard to inhibitory effect on allergen-induced histamine release from passively sensitized human lung tissue and relaxing effect on contracted small (diameter = 1 mm) and large (diameter greater than 3 mm) isolated human bronchi. The dose for 50% inhibition of the allergen-induced histamine release was 2 x 10(-11) M. The potency of KWD 2131 was approximately 0.15 times that of terbutaline and 0.05 times that of isoprenaline in this respect. The bronchodilating potency of KWD 2131 was 0.02-0.03 times that of terbutaline. The data indicate that KWD 2131 is a compound with preferably anti-anaphylactic potency in the human lung.

摘要

已对β-肾上腺素能受体激动剂KWD 2131进行了研究，观察其对变应原诱导的被动致敏人肺组织组胺释放的抑制作用，以及对离体人小（直径 = 1 mm）和大（直径大于3 mm）支气管收缩的舒张作用。变应原诱导组胺释放50%抑制的剂量为2×10⁻¹¹ M。在这方面，KWD 2131的效力约为特布他林的0.15倍，异丙肾上腺素的0.05倍。KWD 2131的支气管舒张效力为特布他林的0.02 - 0.03倍。数据表明，KWD 2131是一种在人肺中具有较好抗过敏效力的化合物。