Pató E, Radó J
Fövárosi Uzsoki utcai Kórház III. Belgyógyászati (Nephrologia-Hypertonia) Osztály.
Orv Hetil. 1997 Jul 27;138(30):1903-7.
Authors studied the daily dose of angiotensin converting enzyme inhibitor captopril and enalapril in patients with hypertension on regular hemodialysis of three hemodialysis units, and the relationship between the daily doses of angiotensin converting enzyme inhibitors and the number of simultaneously used other antihypertensive agents in the same patients. 104 out of 133 hemodialysed patients were treated with antihypertensive agents, 53 patients received angiotensin converting enzyme inhibitor. The data of 23 captopril treated patients in 3 dialysis units and data of 17 enalapril treated patients in 2 dialysis units were used as the basis of the study. The difference between the average daily doses of captopril applied at the different hemodialysis units was significant (111, 61 and 26 mg/day). However the difference between the average doses of enalapril was not significant (18 and 12.9 mg/day). The correlation was found to be significant between the dose of captopril and the number of simultaneously used antihypertensive agents: r = 0.46, p < 0.05. The correlation was also significant between the dose of enalapril and the number of combinations of other antihypertensive agents: r = 0.50, p < 0.05. These relations and the analysis of antihypertensive therapy of 4 patients, receiving the largest doses of captopril suggest that larger doses of angiotensin converting enzyme inhibitors were used in the more resistant hypertensive patients, where more antihypertensive agents were needed to be administered to control the blood pressure.
作者研究了三个血液透析单位中接受常规血液透析的高血压患者使用血管紧张素转换酶抑制剂卡托普利和依那普利的日剂量，以及同一患者中血管紧张素转换酶抑制剂日剂量与同时使用的其他抗高血压药物数量之间的关系。133例接受血液透析的患者中有104例接受了抗高血压药物治疗，53例患者接受了血管紧张素转换酶抑制剂治疗。以3个透析单位中23例接受卡托普利治疗的患者的数据和2个透析单位中17例接受依那普利治疗的患者的数据作为研究基础。不同血液透析单位应用的卡托普利平均日剂量之间存在显著差异（分别为111、61和26毫克/天）。然而，依那普利的平均剂量之间差异不显著（分别为18和12.9毫克/天）。发现卡托普利剂量与同时使用的抗高血压药物数量之间存在显著相关性：r = 0.46，p < 0.05。依那普利剂量与其他抗高血压药物联合使用数量之间也存在显著相关性：r = 0.50，p < 0.05。这些关系以及对4例接受最大剂量卡托普利治疗患者的抗高血压治疗分析表明，在更难控制的高血压患者中使用了更大剂量的血管紧张素转换酶抑制剂，这些患者需要使用更多的抗高血压药物来控制血压。
