Kobler E, Werth B, Wüst W, Reinhart W H
Gastroenterologie und Medizinische Klinik, Kantonsspital Chur.
Schweiz Med Wochenschr Suppl. 1997;89:14S-16S.
There is evidence that triple therapy with two antibiotics and a proton pump inhibitor is more cost-effective than various dual therapies for the eradication of Helicobacter pylori. We have analyzed the effectiveness and acceptability of the so-called "Italian protocol" (clarithromycin 250 mg b.i.d., metronidazole 500 mg b.i.d. and omeprazole 20 mg daily for one week, followed by 20 mg omeprazole daily for further 3 weeks) in a prospective study of 36 patients with Helicobacter pylori-associated ulcers (10 gastric ulcers, 26 duodenal ulcers). Primary eradication was achieved in 35 out of 36 patients (96%). Side effects such as dysgeusia and diarrhea were rare and rapidly reversible. We conclude that this triple therapy was cost-effective and well tolerated in our study population.
有证据表明，两种抗生素与一种质子泵抑制剂的三联疗法在根除幽门螺杆菌方面比各种双联疗法更具成本效益。我们在一项对36例幽门螺杆菌相关性溃疡患者（10例胃溃疡，26例十二指肠溃疡）的前瞻性研究中，分析了所谓“意大利方案”（克拉霉素250mg，每日2次；甲硝唑500mg，每日2次；奥美拉唑20mg，每日1次，共1周，随后奥美拉唑20mg，每日1次，再持续3周）的有效性和可接受性。36例患者中有35例（96%）实现了初次根除。味觉障碍和腹泻等副作用很少见，且可迅速逆转。我们得出结论，在我们的研究人群中，这种三联疗法具有成本效益且耐受性良好。
