Edeleva N V, Osipova M A, Nemtsova E R, Sergeeva T V, Oganezov V K, Iakubovskaia R I, Vetsheva M S, Beresnev V A
Anesteziol Reanimatol. 1997 May-Jun(3):36-41.
The functional status of the oxidative-antioxidative system was studied in 72 patients after vast cancer operations. Traditional surgical treatment and its combination with intraoperative irradiation were shown to lead to tense antioxidative defense and to suppressed T-cell immunity and to call for antioxidative and immunomodulating therapy. High intraoperative blood loss complicated by hemorrhagic shock injured the oxidative-antioxidative system greatly. The magnitude of this damage correlated with the rate of prehypoxia. Addition of the potent antioxidant Ceruloplasmin to the drug regimen normalized a recovery period, helped to correct posthypoxic multiorgan insufficiency, to recover oxidative-antioxidative balance, and to decrease the incidence of pyoinflammatory complications. Patients with endogenous intoxication showed activated lipid peroxidation, decreased functional activity of antioxidative defense components and of T-cell immunity in homeostasis. The use of Ceruloplasmin and Laprot had pronounced antiinflammatory and detoxifying effects on the patient's body and activated its antioxidative defense.
对72例接受大型癌症手术后的患者的氧化 - 抗氧化系统功能状态进行了研究。结果显示，传统手术治疗及其与术中放疗相结合会导致抗氧化防御紧张、T细胞免疫受到抑制，因此需要进行抗氧化和免疫调节治疗。术中大量失血并发失血性休克会严重损害氧化 - 抗氧化系统。这种损害的程度与缺氧前期的发生率相关。在药物治疗方案中添加强效抗氧化剂铜蓝蛋白可使恢复期正常化，有助于纠正缺氧后多器官功能不全，恢复氧化 - 抗氧化平衡，并降低脓性炎症并发症的发生率。内源性中毒患者在体内平衡状态下表现出脂质过氧化激活、抗氧化防御成分和T细胞免疫功能活性降低。使用铜蓝蛋白和拉普罗特对患者身体具有显著的抗炎和解毒作用，并激活其抗氧化防御。
