Bhatia D S, Allen J E
Department of Surgery, Ochsner Clinic, New Orleans, Louisiana, USA.
Am Surg. 1997 Sep;63(9):775-7.
For many years, various substances have been used to prevent postoperative adhesions, with suboptimal effectiveness. Saline has been postulated to have a positive effect, but it is reabsorbed from the abdominal cavity within 24 hours. To determine whether a longer-lasting intraperitoneal solution would be effective in preventing postoperative adhesions, 36 rats were divided into three groups: in 15 rats, a 2.5 per cent hyperosmolar solution of peritoneal dialysis fluid was injected intraperitoneally immediately following exploratory laparotomy, which included traumatization of the intestinal serosa at two sites; in 12 rats, normal saline was injected by the same procedure; and in 9 rats, no fluid was injected after the same operation. After 3 weeks, the group receiving the hyperosmolar peritoneal dialysis solution achieved the best results in both sites, the group that received normal saline showed marginal improvement, and the control group fared the worst.
多年来，人们使用了各种物质来预防术后粘连，但效果并不理想。有人推测生理盐水有积极作用，但它会在24小时内从腹腔被重新吸收。为了确定一种作用更持久的腹腔内溶液是否能有效预防术后粘连，36只大鼠被分为三组：15只大鼠在剖腹探查术后立即腹腔内注射2.5%的高渗腹膜透析液，剖腹探查包括在两个部位对肠浆膜造成创伤；12只大鼠通过相同程序注射生理盐水；9只大鼠在相同手术后不注射液体。3周后，接受高渗腹膜透析液的组在两个部位都取得了最佳效果，接受生理盐水的组有轻微改善，而对照组情况最差。
