Ezberci Fikret, Bulbuloglu Ertan, Ciragil Pinar, Gul Mustafa, Kurutas Ergul Belge, Bozkurt Serdar, Kale I Taner
Department of Surgery, University of Kahramanmaras, Genel Cerrahi ABD, Turkey.
Surg Today. 2006;36(4):361-6. doi: 10.1007/s00595-005-3137-x.
We investigated the effects of intraperitoneal tenoxicam on the development of postoperative intra-abdominal adhesions and oxidative stress in a model of bacterial peritonitis.
Bacterial peritonitis was induced in 24 rats by cecal ligation and puncture. The rats were randomly assigned to one of three groups. Group 1 (n = 8) received 2 ml saline intraperitoneally, group 2 (n = 8) received 2 ml (0.5 mg/kg) tenoxicam (Oksamen) intraperitoneally, and group 3 (n = 8) was a control, which did not receive any injection. All animals were killed 14 days later so we could assess the adhesion score and measure anastomotic bursting pressures. Tissue antioxidant levels were measured in 1-g tissue samples taken from the abdominal wall.
The adhesion score was significantly lower in the tenoxicam group than in the saline and control groups. The anastomotic bursting pressures were higher in the saline and tenoxicam groups than in the control group. The catalase (CAT) levels were higher in the saline and tenoxicam groups than in the control group. The malondialdehyde (MDH) levels were higher in the saline group than in the tenoxicam and control groups.
Intraperitoneal tenoxicam inhibited the formation of postoperative intra-abdominal adhesions without compromising wound healing in this bacterial peritonitis rat model. Tenoxicam also decreased the oxidative stress during peritonitis.
我们在细菌性腹膜炎模型中研究了腹腔注射替诺昔康对术后腹腔粘连形成及氧化应激的影响。
通过盲肠结扎和穿刺在24只大鼠中诱导细菌性腹膜炎。将大鼠随机分为三组。第1组（n = 8）腹腔内注射2 ml生理盐水，第2组（n = 8）腹腔内注射2 ml（0.5 mg/kg）替诺昔康（奥沙美辛），第3组（n = 8）为对照组，不接受任何注射。14天后处死所有动物，以便我们评估粘连评分并测量吻合口破裂压力。从腹壁采集1 g组织样本测量组织抗氧化水平。
替诺昔康组的粘连评分显著低于生理盐水组和对照组。生理盐水组和替诺昔康组的吻合口破裂压力高于对照组。生理盐水组和替诺昔康组的过氧化氢酶（CAT）水平高于对照组。生理盐水组的丙二醛（MDH）水平高于替诺昔康组和对照组。
在该细菌性腹膜炎大鼠模型中，腹腔注射替诺昔康可抑制术后腹腔粘连的形成，且不影响伤口愈合。替诺昔康还可降低腹膜炎期间的氧化应激。
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