Patterns of failure and long-term results in high-risk resected gastric cancer treated with postoperative radiotherapy with or without intraoperative electron boost.
作者信息
Martínez-Monge R, Calvo F A, Azinovic I, Aristu J J, Hernández J L, Pardo F, Fernández P, García-Foncillas J, Alvarez-Cienfuegos J
机构信息
Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain.
出版信息
J Surg Oncol. 1997 Sep;66(1):24-9. doi: 10.1002/(sici)1096-9098(199709)66:1<24::aid-jso6>3.0.co;2-p.
BACKGROUND
To evaluate the possible role of adjuvant radiotherapy in the management of high-risk resected gastric carcinoma.
METHODS
From 1982 to 1993, 62 patients surgically resected of a primary gastric cancer with adverse pathological features (serosal and/or regional lymph node involvement) were treated with postoperative radiotherapy with (Group I) or without (Group II) intraoperative electron boost to the surgical bed and coeliac axis (IORT).
RESULTS
After a median follow-up of 75.6 months (range 4-120+) for IORT patients and 91.2 months (range 6-149+) for non-IORT patients, overall relapse rates for Group I and Group II patients were 44.5% and 48.6% and local-regional relapse rates were 11.1% and 20%, respectively. Actuarial survival rates projected at the maximum follow-up were 41% and 38% in Groups I and II, respectively.
CONCLUSIONS
This retrospective analysis suggests a beneficial effect of adjuvant external radiotherapy in promoting local-regional control in high-risk resected gastric cancer.
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