Proulx G M, Willett C G, Daley W, Shellito P C
Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA.
J Surg Oncol. 1997 Sep;66(1):51-3. doi: 10.1002/(sici)1096-9098(199709)66:1<51::aid-jso10>3.0.co;2-r.
Primary adenocarcinoma of the appendix is rare, which makes an understanding of its natural history difficult. To date, it is treated predominantly with surgery alone. This review aims to elucidate the patterns of failure and treatment outcomes when adjuvant treatment is given after primary surgical resection.
Twenty-three patients were treated with either surgery alone, or with surgery and adjuvant radiation +/- chemotherapy. A review of the clinical course of these patients was undertaken with an analysis of the local control, distant failure, disease-free survival, and overall survival.
Most patients presented with local invasion or metastatic disease often involving the peritoneum. Overall survival was 32%, similar to the results of other studies. Analysis of patients with locally advanced disease showed improvement in overall survival and local control with postoperative radiation therapy compared to surgery alone.
Adenocarcinoma of the appendix is a rare disease that presents most often in an advanced stage. It has been shown by others that a right hemicolectomy provides the best outcome with respect to surgical procedure. Postoperative irradiation appears to provide a benefit for both local control and overall survival.
阑尾原发性腺癌较为罕见，这使得了解其自然病程颇具难度。目前，其主要治疗方式为单纯手术。本综述旨在阐明在原发性手术切除后给予辅助治疗时的失败模式及治疗结果。
23例患者接受了单纯手术治疗，或手术联合辅助放疗及/或化疗。对这些患者的临床病程进行了回顾，并分析了局部控制、远处转移、无病生存期和总生存期。
大多数患者表现为局部侵犯或转移性疾病，常累及腹膜。总生存率为32%，与其他研究结果相似。对局部晚期疾病患者的分析表明，与单纯手术相比，术后放疗可提高总生存率和局部控制率。
阑尾腺癌是一种罕见疾病，多在晚期出现。其他人的研究表明，就手术方式而言，右半结肠切除术效果最佳。术后放疗似乎对局部控制和总生存均有益处。
