Michailova A, Spassov V
Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Gen Physiol Biophys. 1997 Mar;16(1):29-38.
The influence of a change of troponin concentration as well of a change of binding and dissociation of Ca2+ ions to the regulatory protein troponin C on the time course of isometric tension has been studied, using a mathematical model developed to investigate excitation-contraction coupling in cardiac muscle cells. The numerical simulations show that peak amplitude, rate of force development, time to peak tension and relaxation time depend significantly on the above parameters even in the case when the equilibrium dissociation constant remains unchanged. The obtained results might be useful for the planing of new experiments in the view of the fact that no similar data have been reported for cardiac muscle cells as yet.
利用为研究心肌细胞兴奋 - 收缩偶联而开发的数学模型，研究了肌钙蛋白浓度变化以及钙离子与调节蛋白肌钙蛋白C的结合和解离变化对等长张力时间进程的影响。数值模拟表明，即使在平衡解离常数保持不变的情况下，峰值幅度、力发展速率、达到峰值张力的时间和松弛时间也显著依赖于上述参数。鉴于目前尚未有关于心肌细胞的类似数据报道，所得结果可能有助于规划新的实验。
