Job C K, Jayakumar J, Aschhoff M
Leprosy Department, St Thomas Hospital & Leprosy Centre, Chettupattu.
Indian J Lepr. 1997 Apr-Jun;69(2):131-42.
Thirty paucibacillary (PB) patients were given multidrug therapy (MDT) PB regimen for six months and were examined clinically and histopathologically before therapy, at six months and 12 months after therapy; and in four patients, at 18 to 23 months after MDT. Histopathological activity was present in 50% and 25% of patients after six months and 12 months respectively after MDT. At 18 to 23 months, the four patients continued to have active lesions both clinically and histopathologically. On the basis of this study it is found that fixed duration of MDT is effective in a large majority of patients especially those with indeterminate leprosy. However, there is "delayed resolution" in a significant number of patients which in a few instances may turn out to be "treatment failures". Therefore, a regular follow up of high risk patients for at least two years and if possible, five years, with freedom to intervene with additional anti-inflammatory or antileprosy therapy as desired, is recommended.
30例少菌型（PB）患者接受了为期6个月的多药联合治疗（MDT）PB方案，并在治疗前、治疗后6个月和12个月进行了临床和组织病理学检查；4例患者在MDT治疗后18至23个月进行了检查。MDT治疗后6个月和12个月时，分别有50%和25%的患者存在组织病理学活动。在18至23个月时，这4例患者在临床和组织病理学上均持续存在活动性病变。基于这项研究发现，固定疗程的MDT对大多数患者有效，尤其是那些未定类麻风患者。然而，相当一部分患者存在“延迟缓解”，在少数情况下可能会演变为“治疗失败”。因此，建议对高危患者进行至少两年的定期随访，如有可能，随访五年，并可根据需要自由进行额外的抗炎或抗麻风治疗干预。
