硫糖铝对危重症患者胃黏膜内pH值的影响。

Effect of sucralfate on gastric intramucosal pH in critically ill patients.

作者信息

Calvet X, Baigorri F, Duarte M, Joseph D, Saura P, Mas A, Royo C, Artigas A

机构信息

Internal Medicine Department, Hospital de Sabadell, Barcelona, Spain.

出版信息

Intensive Care Med. 1997 Jul;23(7):738-42. doi: 10.1007/s001340050402.

DOI:10.1007/s001340050402

PMID:9290986

Abstract

OBJECTIVE

To determine whether sucralfate administration affects the tonometric measurement of gastric intramucosal pH (pHi).

DESIGN

Non-randomized observational study.

SETTING

General intensive care unit of a teaching hospital.

PATIENTS

Twenty critically ill, mechanically ventilated, consecutively admitted patients requiring an arterial catheter and nasogastric tube.

INTERVENTIONS

Tonometer placement and sucralfate administration.

MEASUREMENTS AND MAIN RESULTS

We simultaneously determined tonometer saline PCO2 (PCO2i), arterial blood gases, pH of gastric juice and pHi. These parameters were evaluated immediately before sucralfate administration, and 2 h and 4 h after. We did not detect any change in either PCO2i or pHi after sucralfate administration (PCO2i: basal 6.4 +/- 1.7, 2 h 6.3 +/- 1.7, 4 h 6.3 +/- 1.7; pHi: basal 7.35 +/- 0.13, 2 h 7.36 +/- 0.12, 4 h 7.36 +/- 0.12).

CONCLUSIONS

Sucralfate does not affect the tonometric measurement of PCO2i and pHi.

摘要

目的

确定给予硫糖铝是否会影响胃黏膜内pH值（pHi）的张力测定。

设计

非随机观察性研究。

地点

一家教学医院的综合重症监护病房。

患者

20例连续收治的危重症机械通气患者，均需要动脉导管和鼻胃管。

干预措施

放置张力计并给予硫糖铝。

测量指标及主要结果

我们同时测定了张力计盐水PCO2（PCO2i）、动脉血气、胃液pH值和pHi。在给予硫糖铝之前、之后2小时和4小时对这些参数进行评估。给予硫糖铝后，我们未检测到PCO2i或pHi有任何变化（PCO2i：基础值6.4±1.7，2小时6.3±1.7，4小时6.3±1.7；pHi：基础值7.35±0.13，2小时7.36±0.12，4小时7.36±0.12）。